| 1.2 | Class: Basic helix-loop-helix factors (bHLH), Alignment |
| Aligned bHLH domain sequences: | |
RRVANNARERLRVRDINEAFKELGRMCQLHLNSEKP------QTKLLILHQAVSVILNLE E2A RRMANNARERLRVRDINEAFKELGRMVQLHLKSDKP------QTKLLILHQAVAVILSLE SEF2 RRMANNARERLRVRDINEAFKELGRMCQLHLKSEKP------QTKLLILHQAVAVILSLE HTF4 RRKAATMRERRRLSKVNEAFETLKRCTSSN-PNQ-------RLPKVEILRNAIRYIEGLQ MyoD1 RRRAATLREKRR-KKVNEAFEALKRSTLLN-PNQ-------RLPKVEILRSAIQYIERLQ Myogenin RRKAATMRERRRLKKVNQAFETLKRCTTTN-PNQ-------RLPKVEILRNAIRYIESLQ Myf5 RRKAATLRERRRLKKINEAFEALKRRTVAN-PNQ-------RLPKVEILRSAISYIERLQ Myf6 AVARRNERERNRVKLVNLGFATLREHV-PNGAAN------KKMSKVETLRSAVEYIRALQ ASH1 AVARRNERERNRVKLVNLGFQALRQHV-PHGGAS------KKLSKVETLRSAVEYIRALQ ASH2 FTRKRNERERQRVKCVNEGYAQLRHHL-PEEYLE------KRLSKVETLRAAIKYINYLQ ASH3 FLRKRNERERQRVRCVNEGYARLRDHL-PRELAD------KRLSKVETLRAAIDYIKHLQ ASH4 FIQKRNERERQRVKCVNEGYARLRGHL-PGALAE------KRLSKVETLRAAIRYIKYLQ ASH5 RRIFTNSRERWRQQNVNGAFAELRKLI-PTHPPD------KKLSKNEILRLAMKYINFLA TAL1 RKIFTNTRERWRQQNVNSAFAKLRKLI-PTHPPD------KKLSKNETLRLAMRYINFLV TAL2 RRVFTNSRERWRQQNVNGAFAELRKLL-PTHPPD------RKLSKNEVLRLAMKYIGFLV Lyl1 YRTAHATRERIRVEAFNLAFAELRKLL-PTLPPD------KKLSKIEILRLAICYISYLN HEN1 YRSAHATRERIRVEAFNLAFAELRKLL-PTLPPD------KKLSKIEILRLAICYISYLN HEN2 QRVMANVRERQRTQSLNEAFAALRKII-PTLPSD-------KLSKIQTLKLAARYIDFLY TWIST1 QRILANVRERQRTQSLNEAFAALRKII-PTLPSD-------KLSKIQTLKLAARYIDFLY TWIST2 RKGSGPKKERRRTESINSAFAELRECI-PNVPAD------TKLSKIKTLRLATSYIAYLM HAND1 RRGTANRKERRRTQSINSAFAELRECI-PNVPAD------TKLSKIKTLRLATSYIAYLM HAND2 QRQAANARERDRTQSVNTAFTALRTLI-PTEPVD------RKLSKIETVRLASSYIAHLA bHLH-EC2 QRHTANARERDRTNSVNTAFTALRTLI-PTEPAD------RKLSKIETLRLASSYISHLG SCX LRQAANVRERRRMQSINDAFEGLRSHI-PTLPYE------KRLSKVDTLRLAIGYINFLS PTF1A RRRVANAKERERIKNLNRGFARLKALV-PFLPQS------RKPSKVDILKGATEYIQVLS FIGA QRQSASEREKLRMRTLARALHELRRFL-PPSVA--PA--GQSLTKIETLRLAIRYIGHLS Mesp1 QRQSASEREKLRMRTLARALHELRRFL-PPSLA--PA--GQSLTKIETLRLAIRYIGHLS Mesp2 ASPENAARERSRVRTLRQAFLALQAAL-PAVPPD------TKLSKLDVLVLAASYIAHLT TCF23 QRNAANARERARMRVLSKAFSRLKTSL-PWVPPD------TKLSKLDTLRLASSYIAHLR ABF1 QRNAANARERARMRVLSKAFSRLKTTL-PWVPPD------TKLSKLDTLRLASSYIAHLR Pod1 RRRKASEREKLRMRTLADALHTLRNYL-PPVYSQR----GQPLTKIQTLKYTIKYIGELT MSGN1 RRMKANARERNRMHGLNAALDNLRKVV-PCYSKT------QKLSKIETLRLAKNYIWALS NeuroD1 RRQKANARERNRMHDLNAALDNLRKVV-PCYSKT------QKLSKIETLRLAKNYIWALS NeuroD2 RRVKANARERTRMHGLNDALDNLRRVM-PCYSKT------QKLSKIETLRLARNYIWALS NeuroD4 RRQEANARERNRMHGLNDALDNLRKVV-PCYSKT------QKLSKIETLRLAKNYIWALS NeuroD6 RRVKANDRERNRMHNLNAALDALRSVL-PSFPDD------TKLTKIETLRFAYNYIWALA NGN1 RRLKANNRERNRMHNLNAALDALREVL-PTFPED------AKLTKIETLRFAHNYIWALT NGN2 RRKKANDRERNRMHNLNSALDALRGVL-PTFPDD------AKLTKIETLRFAHNYIWALT NGN3 RRLAANARERRRMHGLNHAFDQLRNVI-PSFNND------KKLSKYETLQMAQIYINALS ATH1 RRLAANARERRRMQGLNTAFDRLRRVV-PQWGQD------KKLSKYETLQMALSYIMALT ATH5 RRLLANARERTRVHTISAAFEALRKQV-PCYSY------GQKLSKLAILRIACNYILSLA ATH6 LRLNINARERRRMHDLNDALDELRAVI-PY--AHSPSV--RKLSKIATLLLAKNYILMQA bHLHe22 LRLSINARERRRMHDLNDALDGLRAVI-PY--AHSPSV--RKLSKIATLLLAKNYILMQA bHLHe23 LRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLG OLIGO1 LRLKINSRERKRMHDLNIAMDGLREVM-PY--AHGPSV--RKLSKIATLLLARNYILMLT OLIGO2 LRLKINGRERKRMHDLNLAMDGLREVM-PY--AHGPSV--RKLSKIATLLLARNYILMLT OLIGO3 RRLESNERERQRMHKLNNAFQALREVI-PHVRAD------KKLSKIETLTLAKNYIKSLT MIST1 QRQAANIRERKRMFNLNEAFDQLRRKV-PTFAYE------KRLSRIETLRLAIVYISFMT Fer3L RRMAANVRERKRILDYNEAFNALRRAL-RHDLGG------KRLSKIATLRRAIHRIAALS bHLHa9 RKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHS--KLEKADILEMTVKHLRNLQ HES1 RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCS--KLEKADVLEMTVRFLQELP HES2 -------MEKKRRARINVSLEQLKSLLEKHYSHQIRKR---KLEKADILELSVKYMRSLQ HES3 RKSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHS--KLEKADILEMTVRHLRSLR HES4 NRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNS---KLEKADILEMAVSYLKHSK HES5 RKARKPLVEKKRRARINESLQELRLLLAG-AEVQA------KLENAEVLELTVRRVQGVL HES6 PKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNP--KLEKAEILEFAVGYLRERS HES7 RKRRRGIIEKRRRDRINNSLSELRRLV-PSAFEKQGSA---KLEKAEILQMTVDHLKMLH HEY1 RKKRRGIIEKRRRDRINNSLSELRRLV-PTAFEKQGSA---KLEKAEILQMTVDHLKMLQ HEY2 RKKHRGIIEKRRRDRINSSLSELRRLV-PTAFEKQGSS---KLEKAEVLQMTVDHLKMLH HEYL YKLPHRLIEKKRRDRINECIAQLKDLL-PEHLKLTTLG---HLEKAVVLELTLKHVKALT DEC1 YKLPHRLIEKKRRDRINECIAQLKDLL-PEHLKLTTLG---HLEKAVVLELTLKHLKALT DEC2 GI-KS-NPSKRHRDRLNTELDRLASLL-PFPQDVIN-----KLDKLSVLRLSVSYLRAKS AhR GAEKS-NPSKRHRDRLNAELDHLASLL-PFPPDIIS-----KLDKLSVLRLSVSYLRVKS AhRR MKEKSKNAARTRREKENSEFYELAKLL-PLPSAITS-----QLDKASIIRLTTSYLKMRV SIM1 MKEKSKNAAKTRREKENGEFYELAKLL-PLPSAITS-----QLDKASIIRLTTSYLKMRA SIM2 RKEKSRDAARSRRSKESEVFYELAHQL-PLPHNVSS-----HLDKASVMRLTISYLRVRK HIF1A RKEKSRDAARSRRSQETEVLYQLAHTL-PFARGVSA-----HLDKASIMRLTISYLRMHR HIF3A RKEKSRDAARCRRSKETEVFYELAHEL-PLPHSVSS-----HLDKASIMRLAISFLRTHK EPAS1 RKEKSRNAARSRRGKENLEFFELAKLL-PLPGAISS-----QLDKASIVRLSVTYLRLRR NPAS1 RKEKSRDAARSRRGKENFEFYELAKLL-PLPAAITS-----QLDKASIIRLTISYLKMRD NPAS3 ARENHSEIERRRRNKMTAYITELSDMV-PTCSALA-----RKPDKLTILRMAVSHMKSLR Arnt SRENHSEIERRRRNKMTQYITELSDMV-PTCSALA-----RKPDKLTILRMAVSHMKSMR Arnt2 AREAHSQIEKRRRDKMNSFIDELASLV-PTCNAMS-----RKLDKLTVLRMAVQHMKTLR ArntL FREAHSQTEKRRRDKMNNLIEELSAMI-PQCNPMA-----RKLDKLTVLRMAVQHLRSLK ArntL2 KRVSRNKSEKKRRDQFNVLIKELGSML-PGNAR--------KMDKSTVLQKSIDFLRKHK CLOCK KRASRNKSEKKRRDQFNVLIKELSSML-PGNTR--------KMDKTTVLEKVIGFLQKHN NPAS2 CDTLASSTEKRRREQENKYLEELAELLSANISDIDSLS--VKPDKCKILKKTVDQIQLMK NCoA1 GPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFN--FKPDKCAILKETVKQIRQIK NCoA2 GQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFN--VKPDKCAILKETVRQIRQIK NCoA3 MYRSTKGASKARRDQINAEIRNLKELL-PLAEA-----DKVRLSYLHIMSLACIYTRKGV NPAS4 RRNVISERERRKRMSMSLSCERLRALL-PQFD-------GRREDMASVLEMSVQFLRLAS SOHLH1 CLRRNVISERERRKRMSLSCERLRALL-PQFD-------GRREDMASVLEMSVQFLRLAS SOHLH1 ISLLHSSKEKLRRERIKYCCEQLRTLL-PYVK-------GRKNDAASVLEATVDYVKYIR SOHLH2 RERHNRMERDRRRRRIRICCDELNLLV-PFCNA--------ETDKATTLQWTTAFLKYIQ TCFL5 KKDNHNLIERRRRFNINDRIKELGTLI-PKSSDPEM-----RWNKGTILKASVDYIRKLQ TFE3 KKDNHNLIERRRRFNINDRIKELGMLI-PKANDLDV-----RWNKGTILKASVDYIRRMQ TFEB KKDNHNLIERRRRYNINYRIKELGTLI-PKSNDPDM-----RWNKGTILKASVEYIKWLQ TFEC KKDNHNLIERRRRFNINDRIKELGTLI-PKSNDPDM-----RWNKGTILKASVDYIRKLQ MITF RRAQHNEVERRRRDKINNWIVQLSKII-PDCSMEST--KSG-QSKGGILSKACDYIQELR USF1 RRAQHNEVERRRRDKINNWIVQLSKII-PDCNADNS--KTG-ASKGGILSKACDYIRELR USF2 KRTAHNAIEKRYRSSINDKIIELKDLVVGTEA---------KLNKSAVLRKAIDYIRFLQ SREBP1 RRTTHNIIEKRYRSSINDKIIELKDLVMGTDA---------KMHKSGVLRKAIDYIKYLQ SREBP2 RREIANSNERRRMQSINAGFQSLKTLI-PHTDGE-------KLSKAAILQQTAEYIFSLE AP4 KRRTHNVLERQRRNELKRSFFALRDQI-PELENNE------KAPKVVILKKATAYILSVQ CMYC RRRNHNILERQRRNDLRSSFLTLRDHV-PELVKNE------KAAKVVILKKATEYVHSLQ NMYC KRKNHNFLERKRRNDLRSRFLALRDQV-PTLASCS------KAPKVVILSKALEYLQALV LMYC1 KKKYHSYLERKRRNDQRSRFLALRDEV-PALASCS------RVSKVMILVKATEYLHELA LMYC2 KRAHHNALERKRRDHIKDSFHSLRDSV-PSLQGE-------KASRAQILDKATEYIQYMR MAX AHTQAEQKRRRKGDAIKRGYDDLQTIV-PTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLH MLX RQMKHISAEQKRRFNIKMCFDMLNSLISN---------NSKLTSHAITLQKTVEYITKLQ MLXIP RRITHISAEQKRRFNIKLGFDTLHGLVSTLS-AQ----PSLKVSKATTLQKTAEYILMLQ WS-bHLH SRSTHNEMEKNRRAHLRLCLEKLKGLV-PLGPESS------RHTTLSLLTKAKLHIKKLE MAD GRSVHNELEKRRRAQLKRCLERLKQQM-PLGADCA------RYTTLSLLRRARMHIQKLE MAD3 NRSSHNELEKHRRAKLRLYLEQLKQLV-PLGPDST------RHTTLSLLKRAKVHIKKLE MAD4 YRRTHTANERRRRGEMRDLFEKLKITL-GLLHSS-------KVSKSLILTRAFSEIQGLT MAD5 NRSTHNELEKNRRAHLRLCLERLKVLI-PLGPDCT------RHTTLGLLNKAKAHIKKLE MXI1 TREVHNKLEKNRRAHLKECFETLKRNI-PNVDDK-------KTSNLSVLRTALRYIQSLK MNT